Translation initiation sites that precede the main coding sequence (CDS) of a transcript give rise to upstream open reading frames (uORFs). The presence of uORFs affects initiation rates at the CDS by interfering with unrestrained progression of ribosomes across the 5´-transcript leader sequence.
Accumulating evidence suggests that uORF-mediated translational control is of outstanding importance for the regulation of protein expression in health and disease.
- aims to collect all literature on uORF biology in eukaryotic organisms, including viral transcripts
- categorizes individual uORF-related publications by a variety of denominators, including taxon, gene, and the type of study. [read more]
- can be queried for multiple structural and functional uORF-related properties to allow convenient and targeted access to the complex field of uORF biology
The current version (v1.0, 2013/07/15) provides links to 467 references in PubMed addressing uORF functions in various taxa and genes as summarized below. [read more]